Phospholipid Research Center | Reference Literature
page-template-default,page,page-id-16583,page-child,parent-pageid-16579,ajax_fade,page_not_loaded,,qode-child-theme-ver-1.0.0,qode-theme-ver-15.0,qode-theme-bridge,wpb-js-composer js-comp-ver-5.4.7,vc_responsive

Reference literature


Here you can find some selected useful basic literature on phospholipids and recent interesting phospholipid related reviews:

Books on Phospholipids

  • Cevc G 1993, Phospholipids Handbook, Marcel Dekker Inc.
  • Peeters H 1976. Phosphatidylcholine: Biochemical and Clinical Aspects of Essential Phospholipids, Springer-Verlag.
  • Gunstone H 2008. Phospholipid Technology and Applications (Oily Press Lipid Library, Oily Press).
  • Hanahan DJ 1997. A Guide to Phospholipid Chemistry, Oxford University Press.
  • Szuhaj F 2003. Nutrition and Biochemistry of Phospholipids, CRC Press Inc.

Books on Liposomes

  • Torchilin V 2007. Liposomes: A Practical Approach, OUP Oxford; Second Edition.
  • Basu SC, Basu M 2001. Liposome Methods and Protocols (Methods in Molecular Biology), Humana Press.
  • Gregoriadis G 2007. Liposome Technology, Third Edition, Informa Healthcare.
  • Woodle MC, Storm G 1997. Long Circulating Liposomes: Old Drugs, New Therapeutics: Making Old Drugs New Therapeutics, Springer.
  • Braun-Falco O, Freeston RC 1992. Liposome Dermatics (Griesbach Konferenz Griesbach Conference), Springer.
  • Lasic DD, Barenholz Y 1996. Handbook of Nonmedical Applications of Liposomes, CRC Press Inc.

Review Publications: Parenteral Use of Phospholipids


  • Van Hoogevest P, Liu X, Fahr A, Leigh MLS 2011. Role of phospholipids in the oral and parenteral delivery of poorly water soluble drugs. J Drug Del Sci Tech 21(1):5-16.
  • Mirtallo JM, Dasta JF, Kleinschmidt KC, Varon J 2010. State of the art review: Intravenous fat emulsions: Current applications, safety profile, and clinical implications. Ann. Pharmacother. 44(4):688-700.
  • Fahr A, Van Hoogevest P, May S, Bergstrand N, Leigh MLS 2005. Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery. Eur J Pharm Sci 26(3-4)251-265.


  • Immordino ML, Dosio F, Cattel L 2006. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine. 1(3):297–315.
  • Andresen TL, Jensen SS, Jørgensen K 1995. Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Progress in Lipid Research. 44(1):68-97
  • Gregoriadis G 1995. Engineering liposomes for drug delivery: progress and problems. TIBTECH. 13, 527-537.
  • Bangham AC 1995. Surrogate cells or Trojan horses – The discovery of liposomes. BioEssay. 17, 1081-1088.
  • Chonn A, Cullis PR 1995. Recent advances in liposomal drug-delivery systems. Current Opinion in Biotechnology. 6, 698-708.
  • Margalit R 1995. Liposome-Mediated Drug Targeting in Topical and Regional Therapies. Critical Reviews in Therapeutic Drug Carrier Systems. 12, 233-261.


  • Washington C 1996. Stability of lipid emulsions for drug delivery. Adv Drug Del Rev 20:131-145.
  • Collins-Gold LC, Lyons RT, Bartholow LC 1990. Parenteral emulsions for drug delivery. Adv Drug Del Rev 5:189-208.
  • Hansrani PK, Davis SS, Groves MJ 1983. The Preparation and Properties of Sterile Intravenous Emulsions. J Parenteral Sci Tech 37(4):145-150.
  • Lambert GF, Miller JP, Frost DV 1956, Decomposition of Lecithin in Parenteral Fat Emulsion. Am J Phys 186:397-402.

Mixed micelles

  • Guo J, Wu T, Ping Q, Chen Y, Shen J 2005. Solubilization and Pharmacokinetic Behaviors of Sodium Cholate/Lecithin-Mixed Micelles Containing Cyclosporine A. Drug Del 12:35-39.
  • Lasic DD 1992, Mixed micelles in drug delivery. Nature 355:279-280.
  • Guentert TW, Oie S, Paalzow L, Frey BM, Brandt B, Aarons LJ, Rowland M 1987. Interaction of mixed micelles formed from glycocholic acid and lecithin with the protein binding of various drugs. Br. J. Clin. Pharmac. 23:569-577.
  • Rosoff M, Serajuddin TM 1980. Solubilization of Diazepam in Bile Salts and in Sodium Cholate-Lecithin-Water Phases. Int J Pharm 6:137-146.
  • Gaehwiller C, von Planta C, Schmidt D, Steffen H 1977. Size, Structure, and Dynamics of Bile Salt/Lecithin Mixed Micelles. Z. Naturforschung 32:748-755.

Review Publications: Oral Use of Phospholipids

  • Van Hoogevest P 2017. Review-An update on the use of oral phospholipid excipients. Eur J Pharm Sci 108:1-12.
  • Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, Setzer C, Quinkert R-O, Martin F, Müller-Goymann CC 2010. Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res 27:1469-1489.
  • Van Hoogevest P, Liu X, Fahr A, Leigh MLS 2011. Role of phospholipids in the oral and parenteral delivery of poorly water soluble drugs. J Drug Del Sci Tech 21(1):5-16.

Review Publications: Dermal Use of Phospholipids

  • Pierre MBR, Dos Santos M, Costa I 2011. Liposomal systems as drug delivery vehicles for dermal and transdermal applications. Arch Derm Res 303(9):607-621.
  • Gillet A, Evrard B, Piel G. 2011. Liposomes and parameters affecting their skin penetration behavior. Drug Del Sci Tech 21(1): 35-42.

Review Publications: Inhalation of Phospholipids

  • Willis L, Hayes Jr D, Mansour HM 2012. Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery. Lung 190(3):251-262.
  • Pinheiro M, Lucio M, Lima JLFC, Reis S 2011. Liposomes as drug delivery systems for the treatment of TB. Nanomed 6(8):1413-1428.


  • Szebeni J, Alving CR, Rosivall L, Bünger R, Baranyi L, Bedöcs P, Tóth M, Barenholz Y 2007. Animal Models of Complement-Mediated Hypersensitivity Reactions to Liposomes and Other Lipid-Based Nanoparticles. J Lip Res 17(2)107-117.
  • Krosnjar S, Todic M, Bakic S, Begovic B, Zulic J, Vehabovic M 2005. Oral acute toxicity of polyenylphosphatidylcholine (PPL) in rats. Bosn J Basic Med Sci. 5:63-68.
  • Storm G, Oussoren C, Peeters PAM, Barenholz Y 1993.Tolerability of Liposomes in vivo. in: G. Gregoriadis (Ed.), Liposome Technology, Vol. III, 2nd Edition, CRC Press, Boca Raton, Fl.
  • Parnham MJ 1992. Liposome Phospholipids: Toxicological and Enviromental Advantages. in: O. Braun-Falco, H.C. Korting, H.I. Maibach (Eds.), Liposome Dermatics, Springer Verlag.
  • Besterman EMM, Gillett MPT 1972. A Comparison of the Effects of Saturated and Polyunsaturated Lysolecithin Fractions on Platelet Aggregation and Erythrocyte Sedimentation. Artheriosclerosis. 16:89-94.
  • Nagasaka Y, Inai S, Osumi Y, Takori S, Shimamoto K 1969. Acute and Subacute Toxicities of the Essential Phospholipids Injection. Pharmacomet 3:45-56.


  • Bonekamp A, Fiebig H-J 1999. Bestimmung der Phospholipide durch HPLC. DGF Einheitsmethoden.
  • Wang T, Hammond EG, Cornette JL, Fehr WR 1999. Fractionation of Soybean Phospholipids by High-Performance Liquid Chromatography with an Evaporative Light-Scattering Detector. JAOCS 76:1313-1321.
  • Stueben J, Arseven K, Rebmann B 1997. Determination of Bacterial Endotoxins in Phospholipids by Means of the Limulus Amoebocyte Lysate Test. Pharm. Ind. 59:895-898.
  • Kaufmann P, Olsson U, Herslof BG 1990. A Chemometric Strategy for the Classification of Lecithins According to Process Performance. JAOCS 67:537-540.
  • Allan D, Crockcroft S 1982. A modified procedure for thin-layer chromatography of phospholipids. J Lip Res 23:1373-1374.
  • Erdahl NL, Stolyhwo A, Privett OS 1973. Analysis of Soybean Lecithin by Thin Layer and Analytical Liquid Chromatography. JOACS 50, 513–515.